Intra-cellular traffic: bio-molecular motors on filamentary tracks

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Intra-cellular traffic: bio-molecular motors on filamentary tracks

Debashish Chowdhury†,1 Aakash Basu, Ashok Garai, Philip Greulich, Katsuhiro Nishinari, Andreas Schadschneider, and Tripti Tripathi Department of Physics, Indian Institute of Technology, Kanpur 208016, India Institute for Theoretical Physics, University of Cologne, D-50937 Köln, Germany 3 Department of Aeronautics and Astronautics, Faculty of Engineering, University of Tokyo, Hongo, Bunkyo-ku, T...

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Molecular motors interacting with their own tracks.

Dynamics of molecular motors that move along linear lattices and interact with them via reversible destruction of specific lattice bonds is investigated theoretically by analyzing exactly solvable discrete-state "burnt-bridge" models. Molecular motors are viewed as diffusing particles that can asymmetrically break or rebuild periodically distributed weak links when passing over them. Our explic...

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Traffic jams and shocks of molecular motors inside cellular protrusions.

Molecular motors are involved in key transport processes inside actin-based cellular protrusions. The motors carry cargo proteins to the protrusion tip which participate in regulating the actin polymerization and play a key role in facilitating the growth and formation of such protrusions. It is observed that the motors accumulate at the tips of cellular protrusions and form aggregates that are...

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Traffic of Molecular Motors

Molecular motors perform active movements along cytoskeletal filaments and drive the traffic of organelles and other cargo particles in cells. In contrast to the macroscopic traffic of cars, however, the traffic of molecular motors is characterized by a finite walking distance (or run length) after which a motor unbinds from the filament along which it moves. Unbound motors perform Brownian mot...

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Dynamics of molecular motors with finite processivity on heterogeneous tracks.

The dynamics of molecular motors which occasionally detach from a heterogeneous track like DNA or RNA is considered. Motivated by recent single-molecule experiments, we study a simple model for a motor moving along a disordered track using chemical energy while an external force opposes its motion. The motors also have finite processivity, i.e., they can leave the track with a position-dependen...

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ژورنال

عنوان ژورنال: The European Physical Journal B

سال: 2008

ISSN: 1434-6028,1434-6036

DOI: 10.1140/epjb/e2008-00073-5